Which lab abnormality is most commonly seen with ART toxicity?

• A. Hypokalemia
• B. Hypophosphatemia
• C. Hypoglycemia
• D. Hepatotoxicity (elevated AST/ALT)

Answer: (D)

Drug-induced liver injury is a common concern with antiretroviral therapy, so the most likely lab finding is hepatotoxicity shown by elevated liver enzymes. When hepatocytes are damaged by ART, AST and ALT levels rise, signaling liver injury. Regular monitoring of these enzymes is important, especially in patients with hepatitis B or C coinfection or other liver risks. While electrolyte disturbances or hypoglycemia can occur with various conditions or meds, they are not the typical or most characteristic lab pattern of ART toxicity.